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Charles Ramassamy

Toxines et antioxydants, Alzheimer

 

The main goal of our laboratory is to understand the crucial role of free radicals and oxidative stress on cerebral functions during aging and in some neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. The accumulation free radicals and oxidative stress could induce cell death. On the other hand, free radicals could also be intracellular mediators by activating cell signalling pathways and regulate the expression of some genes involved in neuroprotection. The wide spectrum of activity and distribution of free radicals make them among important biological agents involved in some neurodegenerative diseases such as Alzheimer's or Parkinson's diseases. A better knowledge of their intracellular functions is an essential step to prevent pathology where free radicals are involved.

 

It is well known that free radicals can induce the oxidation of macromolecules such as proteins, lipids and DNA. In Alzheimer’s disease, these by-products of the oxidation macromolecules are detected in vulnerable regions of the brain in early stages of the disease. However, the role of these by-products of oxidation in neurodegeneration remains to be clarified. The objective of our laboratory is to investigate the contribution of these by-products of oxidation in the pathophysiology of Alzheimer’s disease.

 

Free radicals and oxidative stress could be produced following a dysfunction of cellular metabolism. However, they could be generated following exposure to environmental compounds such as pesticides. Another objective of our laboratory is to better understand the role of these compounds in the pathophysiology of Parkinson’s disease.

 

In parallel, our laboratory investigates the neuroprotective of some natural compounds such as polyphénols present in diet and in natural extracts. In addition to their antioxidant activity, these compounds could have several cellular targets likely involved in neuroprotection. Our objective is to identify polyphenols with neuroprotective activity. At long term, these compounds could be useful in the prevention and treatment of some neurodegenerative disorders.

 

With the aging of the population, treatment of neurodegenerative disorders associated to aging remains a challenge and an active area of research. Using an interdisciplinary approach, our laboratory investigates the development new nanoneuropharmacological tools based on polymeric biocompatible and biodegradable nanoparticles. At long term, these nanoneuropharmacological tools could be useful for the diagnostic, the prevention and the treatment of neurodegenerative disorders by enhancing the bioavailability and the efficacy of pharmacological drugs in the brain.
 

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