Ingénierie enzymatique, RMN, dynamique
Dynamique moléculaire impliquée dans l’activité catalytique des enzymes
531, boulevard des Prairies
Laval (Québec) H7V 1B7
Understanding the importance of residue motion in enzyme activity may eventually allow us to develop methods to modify, modulate and/or design new protein functions, which would have far-reaching implications in biotechnology, protein engineering, nanotechnology and drug design.
The main goal of our research is to successfully modify enzyme biocatalysts aimed at environmental and pharmaceutical applications, with a broader interest focused on understanding the role between structure, function and flexibility in various enzymatic systems.
To address this important problem, our research strategy combines directed evolution experiments coupled with biochemical and biophysical characterization such as nuclear magnetic resonance (NMR), molecular biology, enzyme kinetics, and molecular modeling. Using this approach, we specifically focus on achieving the following aims:
Dr. Nicolas Doucet obtained his B.S. in biochemistry from Université Laval (B.S. Biochemistry, 2000) and successively completed a master's degree (M.S. Biochemistry, 2004) and a doctoral thesis in enzyme engineering at the Université de Montréal (Ph.D. Biochemistry, 2007). After completing a protein NMR postdoctoral fellowship in the Department of Chemistry at Yale University (with J. Patrick Loria, 2007-2010), Dr. Doucet joined the faculty at INRS-Institut Armand-Frappier in 2010.
// 30 juin 2020
Research Grants received in June
// 18 juin 2020
Process of creating a vaccine
// 9 avril 2020
// 5 juillet 2018
A new study published in Molecular Cell
// 28 février 2017
INRS receives over $320,000 from CFI
Dans les médias
// 17 juin 2020
// 17 juin 2020
// 24 mai 2020
// 2 avril 2020
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