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Laurent Chatel-Chaix

Molecular virology

Dengue virus, Zika virus, virus/host interactions

 

Research interests

 

Infection with Dengue virus (DENV) represents a major public health concern since it causes the most prevalent arthropod-borne viral disease with an estimated 400 million individuals infected each year. More recently, the closely related Zika virus (ZIKV) emerged as a global priority since its infection can cause Guillain-Barré syndrome and severe microcephaly in newborns while it is transmissible both sexually and congenitally in addition to infection by mosquito bites.

 

DENV and ZIKV are of particular interest both at the fundamental and clinical levels. Indeed, the mechanistic details known about their life cycle remain enigmatic and as a result, no antivirals or prophylactic vaccines are available against these important emerging diseases.

 

With the aim to better understand the pathogeneses of DENV and ZIKV and to identify novel antiviral targets, my research group concentrates its work on the molecular biology of DENV, ZIKV as well as of other Flaviviridae. More specifically, we aim at discovering novel virus/host interactions engaged in the functional and morphological hijacking of specific cellular machineries by the viral replication factories. Such research encompasses the study of various biological processes such as innate immunity, mitochondria functions, intracellular calcium homeostasis or RNA metabolism. 

 

Biography

 

Dr. Laurent Chatel-Chaix initiated his studies at the University of Grenoble (France) and completed there a Llicense of Cellular Biology and Physiology (1999) and a Master of Cellular Biology and Physiology (2000) in the context of an exchange with the University of Montréal (Canada). He pursued his graduate studies in the University of Montréal where he obtained in 2007 of Ph.D of Biochemistry with a thesis about the interactions between the cellular protein Staufen1 and human immunodeficiency virus type 1 (Laboratory of Drs. Luc DesGroseillers and Andrew Mouland). He carried out his first postdoctoral training (2007-2012) in the laboratory of Dr. Daniel Lamarre (Centre Hôspitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer, Montréal, Canada) in which he discovered novel virus/host interactions required for the infection with hepatitis C virus. Then, he carried on with his postdoctoral training at the University of Heidelberg (Germany) in the laboratory of Dr. Ralf Bartenschlager (2013-2016). Since then, his research focuses on the biology of dengue virus as well as other Flaviviruses such as Zika virus. Dr Chatel-Chaix joined the faculty at INRS-Institut Armand-Frappier in August 2016.

 

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