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Krista Heinonen

Stem cells and hematopoiesis

Emergency myelopoiesis, infection-adapted hematopoiesis, leukemia

 

Research interests

 

All cells of the adult immune system are derived from a small number of bone marrow hematopoietic stem cells (HSC). In addition to being able to develop into the different blood cell lineages, HSC also have the unique capacity to self-renew. The number of HSCs is tightly regulated and unbalanced proliferation and differentiation can lead to multiple immune-related illnesses, such as inflammatory diseases, autoimmunity, immune deficiency and cancer (leukemias and lymphomas).

 

HSC interaction with the bone marrow microenvironment is necessary for their self-renewal. These interactions are often altered in the case of leukemias, for example. On the other hand, one of the technical challenges in the field is to develop methods for stem cell expansion in culture while limiting the loss of their self-renewal capacity. Our research projects can be divided in three main themes:

 

1) the role of Wnt/Frizzled6 signaling in the interactions of HSC with the bone marrow stroma;

2) the role of HSCs in chronic infections; and

3) the impact of Wnt signaling on the development of immune-related pathologies, such as myeloid leukemias.

 

Current projects

 

M.Sc. or Ph.D. student position is currently open. Please send your cv (with contact information for two references), a copy of transcripts and a brief letter of motivation by email.

 

Biography

 

Dr. Heinonen completed her Ph.D. at McGill University in 2006. After a postdoctoral fellowship at the Institute for Research in Immunology and Cancer (IRIC), she joined Institut Armand Frappier in November 2011.

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