Virologie moléculaire et pathogenèse virale
531, boulevard des Prairies
Laval (Québec) H7V 1B7
Dr. Angela Pearson obtained her B.Sc. in Microbiology and Immunology from McGill University, and her Ph.D. in Molecular and Medical Genetics from the University of Toronto. After a postdoctoral fellowship in virology in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, Dr. Pearson joined the faculty at INRS-Institut Armand-Frappier in 2004.
Research in her group is focused on the biology of herpesviruses including the human pathogen herpes simplex virus (HSV) and the veterinary pathogen Canid herpesvirus 1 (CHV-1). HSV infections can be particularly harmful to those with weakened immune systems such as immunosuppressed transplant recipients or those living with AIDS, as well as to newborns due to their immature immune system. In her laboratory, a combination of molecular and cell biological strategies are used to address the following research aims: 1) to elucidate the role of viral genes, in particular the highly conserved UL24 gene, in HSV replication and pathogenesis; 2) to understand the the role of nucleolar proteins during HSV infection. The laboratory has shown that the nucleolar protein Upstream Binding Factor (UBF) inhibits HSV replication. Present work is aimed at understanding the mechanisms involved and at identifying the viral protein(s) that counter UBFs inhibitory activity to allow viral replication in the presence of UBF. The laboratory's research program on CHV-1 is focused on understanding virus-host cell interaction. In particular, work is aimed at identifying the entry pathways for CHV-1 into host cells as well as understanding the impact of CHV-1 on cellular miRNAs of the host.
Research in her laboratory is funded by grants from the National Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes of Health Research (CIHR), the Fonds du Québec recherche sur la nature et les technologies (FQRNT), and the Canada Foundation for Innovation (CFI).
Dans les médias
// 4 octobre 2017
// 4 octobre 2017
// 20 juillet 2016
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